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- _3 value "CPT1c knockout (KO) mice have lower food intake, weigh less and have less body fat, consistent with the role as an energy-sensing malonyl-CoA target. Paradoxically, CPT1c protects against the effects of a high-fat diet. CPT1cKO mice exhibit decreased rates of fatty acid oxidation, consistent with their increased susceptibility to diet-induced obesity. Cpt1c is the neuronal CPT1 enzyme, the rate limiting enzyme of fatty acid beta oxidation." provenance.
- _3 wasQuotedFrom 18719599 provenance.