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- _4 value "Rcor2, Esrrb and Phc1 are examples of transcriptional regulators positively regulated by both Pou5f1 and Nanog factors (via RNAi). The Dkk1 gene, encoding for a Wnt antagonist, is negatively regulated by both Oct4 {Pou5f1} and Nanog (Fig. 6d). One interesting demonstration of Oct4-repressed genes is that of the trophectoderm marker genes Cdx2 and Cldn4: both were markedly upregulated upon Pou5f1 reduction" provenance.
- _4 wasQuotedFrom 16518401 provenance.