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{ <http://www.tkuhn.ch/bel2nanopub/RAH-wQGxdnEqo5FCIbqHvIf8WCKOWRRKICfyZbg2QJiaE#_5> ?p ?o ?g. }
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Thus, TNF-? induces serine phosphorylation of IRS-1 in vitro and serine-phosphorylated IRS-1 acts as an inhibitor of insulin receptor kinase activity and downstream signalling including phosphatidylinositol (PI) 3-kinase activation
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