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- _5 value "p277 However, protein kinase A phosphorylation of the cell surface receptors leads to uncoupled G-protein activity and heterologous desensitization to both the glucagon and catecholamine signals. It is also relevant that protein kinase A can phosphorylate and thereby activate cGMP-inhibited phosphodiesterase which cleaves cAMP and probably helps modulate its effects to minimize desensitization" provenance.
- _5 wasQuotedFrom _4 provenance.