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- _5 value "The MODY-associated transcription factors - hepatocyte nuclear f actor (HNF)4al (associated with MODY 1), HNF-1 alpha (MODY 3), insulin promoter factor 1 (IPF-1 [MODY 4]), HNF-1beta (MODY 5), and neurogenic differentiation factor 1 (NeuroD1), or beta-cell E-box transactivator 2 (BETA2 [MODY 6]) - function in the nucleus of the beta cell and regulate the transcription of the insulin gene (either directly, as in the case of HNF-1a, HNF-1b, IPF-1, and NeuroD1 or BETA2, or indirectly, through effects on the expression of other transcription factors, as in the case of HNF-4a" provenance.
- _5 wasQuotedFrom 11575290 provenance.