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- _4 value "We have previously shown that de novo-synthesized ceramide signals apoptosis in primary astrocytes via activation of the Raf-1/ERK cascade [8]. The e�ect of AICAR on the activity of these two kinases was therefore determined. The palmitate- induced activation of ERK (Fig. 3A) and Raf-1 (Fig. 3B) was prevented by AICAR." provenance.
- _4 wasQuotedFrom 11165240 provenance.