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- _5 value "Leptomycin B binds to the nuclear export mediator protein CRM1, thereby blocking the binding of CRM1 to proteins containing the nuclear export signal (Fukuda et al., 1997) and preventing their nuclear export. During exposure to leptomycin B (40 nM), nuclear HDAC4-GFP continuously increased over a 60-min experimental period, whereas the cytoplasmic fluorescence signal was stable (Fig. 8 A)." provenance.
- _5 wasQuotedFrom 15767461 provenance.