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- _5 value "Ang II also induces ROS in glomerular mesangial (23) and tubular epithelial (12) cells. Ang II-induced ROS in vascular smooth muscle cells were shown to be derived from NADPH oxidase (24). ROS induce AGE (18) and upregulate TGF-1 (4,8), both of which, in turn, induce ROS generation in mesangial cells, high glucose-induced PKC activation in mesangial cells is effectively blocked by antioxidants vitamin E, N-acetyl cysteine (NAC), and taurine, suggesting that ROS mediate high glucose-induced PKC activation." provenance.
- _5 wasQuotedFrom 12874439 provenance.