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- _4 value "However, at several upstream sites of the MRC (most probably complexes I and III), a small fraction of these electrons can directly react with oxygen, to generate the superoxide anion radical. This radical is then dismutated by the mitochondrial manganese superoxide dismutase (MnSOD) into hydrogen peroxide (H2O2), which is detoxified into water by the mitochondrial glutathione peroxidase. Hence, in the normal (non-diseased) state, most of the ROS generated by the MRC is detoxified by the mitochondrial antioxidant defences." provenance.
- _4 wasQuotedFrom 18705745 provenance.