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- _3 value "Up-regulation of functional nAChR {alpha}7 subunits has been shown in normal human bronchial epithelial cells (NHBE) upon exposure to nicotine (10). In SCLC cell lines, up-regulation of nAChR {alpha}7 has been shown in response to NNK stimulation, with overexpression and phosphorylation of serine-threonine protein kinase Raf-1 and extracellular signal regulated kinases 1 and 2 and activation of c-myc (27), leading to increased proliferation (1, 28). " provenance.
- _3 wasQuotedFrom 17510389 provenance.