Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAIaDggXw4HmoY5L4nvb2Dt93wY_S0revK62kYBnpVLv4#_6> ?p ?o ?g. }
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- _6 value "Here, we describe a previously unrecognized pathway for the PH domain-dependent membrane recruitment of Sos that is initiated by the growth factor-induced generation of phosphatidic acid via the signalling enzyme phospholipase D2 (PLD2). Phosphatidic acid interacts with a defined site in the Sos PH domain with high affinity and specificity. This interaction is essential for epidermal growth factor (EGF)-induced Sos membrane recruitment and Ras activation. " provenance.
- _6 wasQuotedFrom 17486115 provenance.