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- _5 value "We show that the functional enhancement of immune responses after STAT3 inhibition is accompanied by up-regulation of several key intracellular signaling molecules that critically regulate T-cell and monocyte activation. Specifically, the phosphorylation of Syk (Tyr(352)) in monocytes and ZAP-70 (Tyr(319)) in T cells are enhanced by the STAT-3 inhibitor in marked contrast to toll-like receptor and T-cell receptor agonists, respectively. " provenance.
- _5 wasQuotedFrom 17942891 provenance.