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{ <http://www.tkuhn.ch/bel2nanopub/RAIemSYaWT2-h72050sKCo-sSDE_cshd7Yu5vFbKc4Z5I#_2> ?p ?o ?g. }
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1) in endothelial cells PDE4 inhibition may up-regulate basal production of NO, this effect being potentiated by PDE2 inhibition; 2) in smooth muscle cGMP produced by NO inhibits PDE3 and increases cAMP level
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