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- _4 value "Treatment of cells with both IL-1 alpha and TNF-alpha resulted in markedly up regulation of COX-2 mRNA and PGE2. The increase in PGE2 production by IL-1 alpha and TNF-alpha was significantly suppressed by aminoguanidine and aspirin, a selective inhibitors of iNOS and COX-2. This indicates that COX-2 mediates the PGE-2 production and nitric oxide potentiates the PGE-2 production." provenance.
- _4 wasQuotedFrom 9383683 provenance.