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- _5 value "Surprisingly, CSC (1, 2.5, and 5%) treatments did not cause any appreciable increase in NF-kB transactivation at 24 h in A549 cells. In preliminary studies, treatment of rat type II epithelial (L2) cells with CSC (1, 5, and 10%) for 4 h did not increase NF-kB DNA binding as assessed by electrophoretic mobility gel shift assay (data not shown) suggesting that CSC has no effect on NF-kB activation or transactivation in epithelial cells as revealed by various techniques. We also assessed the translocation of the p65 subunit of NF-?B from the cytoplasm to nucleus using the Cellomics Arrayscan technology. Using this technique, we showed increased nuclear p65 in response to IL-1b treatment (Fig. 7B), whereas CSC did not result in translocation of p65 from the cytoplasm to nucleus (data not shown)." provenance.
- _5 wasQuotedFrom 15456740 provenance.