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- _6 value "The impact of the Y500F mutation in IL4Ralpha on Th cell differentiation was examined by comparing the in vitro differentiation of wildtype and Y500F T cells into Th1 and Th2 effector lymphocytes in the presence of IL12 and IL4 respectively. The residual production Th2 cytokine IL13 was significantly decreased in Y500F T cell cultures that have been differentiated under Th1 polarizing conditions compared with their wildtype counterparts. This suggests that the Y500 pathway modulated Th cell differentiation by promoting the persistence of Th2 cells in the context of Th1 skewing conditions." provenance.
- _6 wasQuotedFrom 14557412 provenance.