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- _5 value "Figure 4. The role of hypoxia-inducible factor (HIF) in conferring tumour growth potential. In solid tumours, HIFa is stabilised under conditions of low oxygen due to a lack of vascularisation and the subsequent evolution of a hypoxic microenvironment. In a VHL-null tumour, HIFa is constitutively active, and can initiate genetic programmes within the entire population of cells that would normally be activated only under hypoxic conditions." provenance.
- _5 wasQuotedFrom 15350900 provenance.