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- _7 value "involvement of EGFR-PTK in H2O2-induced signaling has been obtained by utilizing AG 1478, a specific inhibitor of tyrosine kinase activity of the EGFR (Table 1) (31).AG 1478 attenuated H2O2-induced ERK1/2 phosphorylation in VSMCs (32) and in rat cardiomyocytes and fibroblasts (30), but had no effect on p38 MAPK phosphorylation (32). In contrast to these studies, AG 1478 failed to block ERK1/2 phosphorylation in response to H2O2 in A10 VSMCs (Fig. 2) (33)." provenance.
- _7 wasQuotedFrom 17406055 provenance.