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- _6 value "The diagram depicts the Sonic hedgehog (SHH)-GLI pathway and shows the transduction of the SHH signal through the Smoothend (SMO)/Patched (PTC) receptor complex. In the absence of the SHH ligand,PTC represses SMO. Signalling is initiated by the binding of SHH to PTC,which relieves the repression of SMO. Subsequently, SMO signals to the nucleus by increasing the concentration of GLI transcription factors,which recruit co-activators to activate downstream target genes." provenance.
- _6 wasQuotedFrom 14570040 provenance.