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- _3 value "A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with imunosuppressant properties. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase" provenance.
- _3 wasQuotedFrom 15251441 provenance.