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- _5 value "The importance of the nitric oxide inhibitory pathway in vivo is shown by two brothers with a defect in the bioavailability of nitric oxide, heightened platelet reactivity to agonists, and a history of cerebrovascular events.100 One common substrate of PKA and PKG is VASP, a 50-kD protein that localizes to focal adhesions and regulates actin dynamics.101 The phosphorylation of VASP on specific serine residues by agents that activate PKA or PKG correlates with inhibition of platelet aggregation.102" provenance.
- _5 wasQuotedFrom 9531572 provenance.