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- _4 value "Initiation of these checkpoints is dependent on the transient recruitment of the MRE11/RAD50/NBS1 (MRN) complex at DSB sites, followed by the recruitment/activation of ataxia?telangiectasia mutated (ATM) a member of the family of phosphoinositide-3-kinase-related kinases (PIKKs) (Su, 2006). In addition, two other PIKKs, DNA-dependent protein kinase (DNA?PK) and ATR (ATM and Rad3 related), are also activated and involved in the response to DSBs." provenance.
- _4 wasQuotedFrom 18285820 provenance.