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- _3 value "p53 also contributes to the G2/M checkpoint through its transactivation of p21 and 14-3-3. P21 effectively blocks the phosphorylation of CDC2, initiating the onset of the G2/M cell-cycle arrest. 14-3-3 sequesters CDC25C in the cytoplasm and promotes the activation ofWee1, a tyrosine kinase that negatively regulates CDC2, thus blocking entry into mitosis." provenance.
- _3 wasQuotedFrom 18285820 provenance.