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- _4 value "Furthermore, the re-introduction of a degradation-resistant mutant of HIF-2a into RCC cells ectopically expressing pVHL abolishes the ability of VHL to suppress the growth of these cell lines [21]. VHL AS A MULTI-FACETED TUMOUR SUPPRESSOR Enhanced cell proliferation Several polypeptide growth factors that stimulate the proliferation of normal cells have pathological consequences for tumourigenesis when deregulated. RCC cells lacking functional pVHL overexpress various growth factors, including platelet-derived growth factor b (PDGFb), VEGF and transforming growth factor (TGF)-a [25]." provenance.
- _4 wasQuotedFrom 15350900 provenance.