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- _5 value "IMR90 and BJ fibroblasts were infected with a retrovirus that expresses the catalytic GAP-related domain (GRD) of neurofibromin. Expression of this domain has previously been shown to decrease Ras-GTP levels (Hiatt et al., 2001; Johannessen et al., 2005). Consistent with these findings, GRD expression resulted in a significant decrease in the activation of AKT and ERK (Figure 3D) and induced senescence in both IMR90 and BJ cells (Figure 3E)" provenance.
- _5 wasQuotedFrom 17157787 provenance.