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- _5 value "The forkhead transcription factor FoxO1 has been identified as a negative regulator of insulin/IGF-1 signaling. Expression of a 3A/LXXAA mutant, in which 3 Akt phosphorylation sites (T24, S253, and S316) and 2 leucine residues in the LXXLL motif (L462 and L463) were replaced by alanine, decreased both Igfbp-1 and G6Pase promoter activity and endogenous Igfbp-1 and G6Pase gene expression in simian virus 40-transformed (SV40-transformed) hepatocytes" provenance.
- _5 wasQuotedFrom 16917544 provenance.