Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RALN4CgGJGKCiVxyvchR4XVL0FiLKRI_YyL_Ent0lKI0o#_6> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _6 value "overexpression of dominant negative (dn) forms of extracellular signal-regulated kinase (ERK)-1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway. Here, we report for the first time the involvement of ERK5 in PMA-inducible SPRR1B transcription in H441 cells. PMA significantly induced ERK5 activation in H441 cells. Overexpression of dn-ERK5 strongly suppressed both basal and PMA-inducible SPRR1B transcription, whereas wild-type ERK5 upregulated it. Consistent with this, a mutant form of MEK-5, an upstream activator of ERK5, strongly suppressed PMA-inducible promoter activity. However, coexpression of c-Jun restored promoter activation suppressed by dn-ERK5. " provenance.
- _6 wasQuotedFrom 12091247 provenance.