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{ <http://www.tkuhn.ch/bel2nanopub/RALap1mH6acRVhra-4I9hqAZIWaQwX7-W9gp-c8k41hRM#_5> ?p ?o ?g. }
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PKC phosphorylates Smad2 in vivo and in vitro at Ser47 and Ser110, and Smad3 at the analogous Ser37 and Ser70 (Yakymovych et al., 2001). Phosphorylation of Smad3 by PKC blocks DNA-binding and consequently transcriptional regulation.
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