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- _4 value "The combined actions of MEF2s and NFATs in the nucleus increase the transcription of prototypical type I muscle fiber genes and, thus, promote fiber-type switching from type II to type I muscle (9). Important experimental evidence for this general model has come from transgenic mice that express either active CnA or CaMKIV (10, 11). In these mice, the relative amount of type I muscle fibers was increased greatly compared with wild-type animals. PGC-1-alpha originally was cloned as a regulator of several aspects of adaptive thermogenesis in brown adipose tissue (12) and subsequently has been found to coactivate a variety of nuclear receptors and other transcription factors (13). PGC-1-alpha also was shown to induce mitochondrial biogenesis and greatly increase respiration when expressed in cultured fat, skeletal, or cardiac muscle cells (14, 15). We recently have discovered that transgenic expression of PGC-1-alpha driven by a muscle-specific promoter results in a dramatic increase of type I muscle fibers (16)." provenance.
- _4 wasQuotedFrom 12764228 provenance.