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- _4 value "A large number of liver-specific or liver-enriched genes which contain HNF3 binding sites have been described previously (reviewed in references 5, 7, 23, and 32). We wanted to know which of these genes are regulated by HNF3gamma in vivo. In order to address this question, we isolated total liver RNA from adult wild-type and mutant animals and analyzed the steady-state mRNA levels of various HNF3 targets by Northern blotting and RNase protection analysis. A subset of these results are shown in Fig. 5A, demonstrating that mRNA levels for TAT, Tf, and PEPCK are reduced in Hnf3g-/- mice, while those of G6Pase, serine dehydratase (SDH), TTR, and albumin are not changed." provenance.
- _4 wasQuotedFrom 9632808 provenance.