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- _3 value "hSP56 mRNA was expressed by LNCaP cells, these cells were replaced from normal FBS (Fetal bovine serum) to the culture medium containing 10% androgen-depleted DCS (dextran-/charcoal-treated FBS). 24-hours of culture in androgen-depleted medium showed that hSP56 mRNA was increased, suggesting androgen may down-regulate hSP56 expression. hSP56 down-regulation by androgen was time- and concentration-dependent. Same results were obtained when cells were treated with DHT (Dihydrotestosterone). (Importantly, hSP56 expression by LNCaP cells was reversibly down-regulated by exogenous androgen in a concentration-dependent manner.)" provenance.
- _3 wasQuotedFrom 9679983 provenance.