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- _8 value "In a second hydroxylation-dependent control, b-hydroxylation of an asparaginyl residue in the C-terminal activation domain of HIF-a (N803 in human HIF-1a) is regulated by a HIF asparaginyl hydroxylase called FIH (factor inhibiting HIF) [62,63]. Hydroxylation at this site prevents the binding of the transcriptional co-activators p300/CBP (CREB binding protein). Under normoxic conditions, these hydroxylation reactions provide a dual mechanism for HIF inactivation that involves proteolytic destruction and the inhibition of transcriptional activity [64]." provenance.
- _8 wasQuotedFrom 15350900 provenance.