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- _5 value "The P13K/Akt signalling pathway results in aggressive proliferation and is activated in most tumors, including gastric adenocarcinoma [107-109]. The tumor suppressor gene, pten (phosphatase and tensin homolog on chromosome ten), inhibits P13K function. Loss of pten expression is associated with P13/Akt signalling activation in many tumors. MiR-19a binds pten in vitro, and overexpression of miR-19 in lymphomas correlates with reduced expression of the Pten protein, thus overexpression of miR-19 in tumors could represent an alternative mechanism of activation of the P13K/Akt signalling pathway [58]." provenance.
- _5 wasQuotedFrom 19412438 provenance.