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- _3 value "Because ceramide up-regulated Txnip expression and reduced thioredoxin activity, we therefore investigated the effect of ceramide on ASK1 activity. The inhibitory residue serine 83 (Ser83) of ASK1 was dephosphorylated after ceramide treatment in both Jurkat T cells (Figure 5A) and 10I cells (Figure S2). This is consistent with the previous findings that Akt/PKB phosphorylates ASK1 Ser83,47 whereas ceramide inhibits Akt/PKB.4,6,48,49" provenance.
- _3 wasQuotedFrom 18270325 provenance.