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- _5 value "His group showed that, in addition to LYN, another SRC-family kinase, FYN, was also required for degranulation and cytokine production by activated mast cells20. This latter pathway did not require LAT and did not lead to the activation of PLCg but, instead, led to the activation of phosphatidylinositol 3-kinase (PI3K) downstream of the phosphorylation of the cytosolic adaptor molecule GAB2 (GRB2-associated binding protein 2)71 (TABLE 2; FIG. 4)." provenance.
- _5 wasQuotedFrom 16470226 provenance.