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- _3 value "We recently reported that SREBP directly suppressed hepatic IRS-2 expression and caused insulin resistance in the liver (25). In accordance with changes in SREBP-1c in islets, IRS-2 was strongly suppressed by palmitate and was partially restored by addition of EPA, implicating a role for SREBP-1c?mediated IRS-2 repression in the palmitate-EPA?mediated changes in ?-cell physiology" provenance.
- _3 wasQuotedFrom 18458149 provenance.