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- _4 value "Plasmids containing ADH3-cat were transfected into HepG2 cells either alone or with expression plasmids for C/EBP-alpha, LAP, DBP, or HNF-1. ADH3 promoter responded quite well to DBP, a very significant synergistic effect for the ADH3 promoter was observed when cells were co-transfected with C/EBP-alpha and LAP expression vectors. The induction levels for ADH3 were 1.5-fold for C/EBP-alpha alone and 3.5-fold for LAP alone but was 20-fold for the mixture (10 microgram of each expression plasmid), indicating a clear synergistic effect. The more significant synergistic effect on ADH3 suggests that C/EBP-alpha and LAP may not be able to effectively transactivate this promoter individually but instead must work together." provenance.
- _4 wasQuotedFrom 1620113 provenance.