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- _3 value "Among genes modulated in all patients upregulation predominated in the cell cycle proliferation category (JUNB, S100A10, and PPARG) and slightly in the cell adhesion and cytoskeleton category (CTTN, KAL1, and MXRA8). On the contrary, in the category of protein transport/metabolism genes, downregulation (18.9%) slightly overcame upregulation (14.3%). The former included RAB27A involved in protein transport and also in small GTPase-mediated signal transduction, SYT11, RPE, TTC7L1, and ANKIB1 involved in ubiquitin-dependent protein catabolism, the mitochondrial carrier protein MCART6 and CRLS1, a synthase involved in phospholipid biosynthesis, while upregulated genes included PDZRN3 involved in protein ubiquitination, PPIG, a peptidyl-prolyl isomerase accelerating protein folding and also involved in regulation of pre-mRNA splicing, and the translation initiation factor EIF3S2, besides a mannosidase (MAN1C1) involved in glycosylation." provenance.
- _3 wasQuotedFrom 18508997 provenance.