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- _4 value "Ang II stimulated phosphorylation of ERK1/2 in VSMCs of SHR and WKY. Ang II induced a 4-5-fold increase in ERK1/2 activity in SHR compared with WKY and the responses were maximal at 5 minutes. Irbesartan (an AT1R inhibitor) abrogated Ang II induced ERK1/1 activity suggesting that the Ang II induced ERK1/2 activation is mediated via AT1R." provenance.
- _4 wasQuotedFrom 11230337 provenance.