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- _4 value "Stimulation of PKCs in U-251 cells for 30 min with 100 nM PMA, showed an increased phosphorylation of mTOR at ser-2448 by 43+/-10-fold compared with untreated cells. Expression of PKC-etaKR, a kinase dead mutant of PKCeta significantly reduced PMA stimulated ser-2448 phosphorylation of mTOR by 54+/-12%. In U-1242 PKCdeltaNPS, a catalytically active PKC expression increased phosphorylation on ser-2448 of mTOR by 322+/-58% as compared to the empty vector, suggesting that PKCeta activates mTOR." provenance.
- _4 wasQuotedFrom 15489897 provenance.