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- _4 value "Loss of p27kip1 expression in cancer primarily occurs through sustained protein degradation, a four-step process that requires phosphorylation of p27kip1 at threonine 187 by cyclin E/cdk, recognition of T187-phosphorylated p27kip1 by the ubiquitin ligase SCFSkp2, ubiquitylation, and degradation by the 26S proteasome of T187-phosphorylated p27kip1. Cytoplasmic retention of p27kip1 may occur through increased export or reduced import. Interaction of p27kip1 with JAB1/CNS5 or phosphorylation of serine 10 (S10) by the hKIS kinase promotes p27kip1 export from the nucleus, whereas phosphorylation of threonine 157 (T157) by the protein kinase B/AKT (AKT) impairs its import." provenance.
- _4 wasQuotedFrom 15743786 provenance.