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- _3 value "Mapping studies revealed that the ability of E2F1 to induce apoptosis requires its DNA-binding domain but not its transactivation function [35,36], which suggests that proapoptotic E2F1 target genes are activated by removing E2F1/RB repression rather than by direct trans-activation The p53-homolog p73 has been described as the first downstream mediator of E2F1-induced apoptosis in the absence of p53." provenance.
- _3 wasQuotedFrom 16530485 provenance.