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- _5 value "DAF-16 and its mammalian homologues, including FKHR (FOXO1), FKHRL1 (FOXO3a), and AFX (FOXO4) interact directly with IRSs from the IGFBP-1 promoter in a sequence-specific fashion in in vitro assays and in cells. In liver-derived cells, FOXO proteins stimulate the activity of promoters for IGFBP-1, glucose-6 phosphatase, and PEPCK. In other cell types, FOXO proteins also stimulate the expression of proteins that inhibit cell cycle progression, including p27Kip, Rb2, and GADD45, and proteins that promote cells death, including Bim and Fas ligand." provenance.
- _5 wasQuotedFrom 12228231 provenance.