Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAOoX2mVU1wnPeycAmRUxXmJ1rTES2NlqgC9BMWTQuuAs#_2> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _2 value "We reported that the endoplasmic reticulum (ER) stress pathway involving CHOP, a member of the C/EBP transcription factor family, plays a key role in nitric oxide (NO)-mediated apoptosis of macrophages and pancreatic beta cells. We also showed that the cytosolic chaperone pair of hsp70 and dj1 (hsp40/hdj-1) or dj2 (HSDJ/hdj-2) prevents NO-mediated apoptosis upstream of cytochrome c release from mitochondria. To analyze roles of the chaperone pair in preventing apoptosis, RAW 264.7 macrophages stably expressing hsp70 and dj1 or dj2 were established. The chaperone pair prevented LPS/IFN-gamma-induced and NO-mediated apoptosis downstream of CHOP induction." provenance.
- _2 wasQuotedFrom 14752510 provenance.