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- _6 value "Notch1 exerts its tumour-suppressive effect in the mouse skin partially by repressing components of the Wnt (see a) and Shh (see b) signalling pathways.Activation of both pathways has been associated with many forms of cancer.Activation of WNT signalling has been linked with colorectal cancer, hepatocellular tumours, pilomatricomas, melanomas and other types of cancer (for a review, see REF. 98).Aberrant SHH signalling has been associated with sporadic basal-cell carcinoma, medulloblastoma and rhabdomyosarcoma (for a review, see REF. 138)." provenance.
- _6 wasQuotedFrom 14570040 provenance.