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- _8 value "he CD28 signaling pathway primarily involves a small subset of signaling molecules that are also implicated in TCR signal transmission, in particular the phosphoinositide-3 kinase (PI3-K) pathway with downstream activation of AKT [32,33], and activation of TEC protein kinases and of interleukin-2-inducible T-cell kinases [27,34]. AKT activation cooperates with the TCR-induced activation of protein kinase C (PKC)? to activate the NF-?B pathway, which is otherwise only slightly activated by TCR alone. " provenance.
- _8 wasQuotedFrom 19007423 provenance.