Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAPPBcf7J_sFk2ZOVt_hTaWfRySz2P4ZYds40Fr3rXOcQ#_5> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _5 value "phosphorylation by PKA strongly repressed the binding affinity of the wild-type factor but not that of HNF4 mutants. Accordingly, in transfection assays, expression vectors for the mutated HNF4 proteins activated transcription more efficiently than that for the wild-type protein-when cotransfected with the PKA catalytic subunit expression vector. Therefore, HNF4 is a direct target of PKA which might be involved in the transcriptional inhibition of liver genes by cAMP inducers.from full text (mutated HNF4 proteins at positions 133 and 134 Serine." provenance.
- _5 wasQuotedFrom 9234678 provenance.