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- _4 value "Both dominant-negative and chemical reagents were used to establish the finding that p38 MAPK signaling can trigger cell senescence. One report systematically showed that p38 MAPK activity was responsible for executing senescence in response to all the known stimuli telomere shortening, H2O2 exposure, and chronic RAS oncogene signaling (Haq et al., 2002; Wang et al., 2002 and Iwasa et al., 2003). When considered together, several papers also suggest that p38 MAPK activation is linked to tumor suppression (Bulavin et al., 2002; Pruitt et al., 2002; Brancho et al., 2003 and Liao and Hung, 2003)." provenance.
- _4 wasQuotedFrom 15225871 provenance.