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{ <http://www.tkuhn.ch/bel2nanopub/RAPchxz5oskrImhijsRTjusYDlGLJ9X1_YhWpvJCdlrAo#_3> ?p ?o ?g. }
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When applied to myotube cultures in vitro, rapamycin blocks activation of p70S6K downstream of either activated Akt1 or IGF-1 stimulation [6,17,53]. Treatment with rapamycin decreases hypertrophy [17] and muscle growth [53].
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