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- _4 value "The relationship between NOX-mediated oxidant signaling and tyrosine phosphorylation was first indicated by pioneering studies by Finkel and Rhee and their co-workers (39,40), who demonstrated that the activation of receptor tyrosine kinases by growth factors, such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF), is associated with transient and regulated cellular production of H2O2, which amplifies tyrosine kinase signaling by temporally inactivating a protein tyrosine phosphatase (PTP)." provenance.
- _4 wasQuotedFrom 18164271 provenance.